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The genus Borrelia, in the spirochete phylum, is not closely
related to any other bacteria and has a highly unusual genome
composed of a linear chromosome and multiple circular and linear
plasmids that appear to be in a constant state of rearrangement,
recombination, and deletion. The determination of the genome
sequence of Borrelia strains has facilitated tremendous advances in
understanding this genus at the molecular and cellular level, as
well as the pathogenesis of Lyme disease and relapsing fever. In
recent years, there has been an explosion of new insights into the
molecular biology, genetics, physiology, and ecology of Borrelia
and its tick/vertebrate life cycle. This research is of particular
importance as the incidence of Lyme borreliosis continues to
increase. Written by renowned scientists who have made seminal
contributions to the field, this book is a comprehensive guide to
the pathogenic Borrelia, providing researchers, advanced students,
clinicians, and other professionals with an encyclopedic overview
of the molecular biology of this important genus and the
pathogenesis of diseases. Leading authorities have made
contributions on topics such as Borrelia genomics, DNA replication,
gene regulation, transcriptomics, proteomics, metabolism and
physiology, cellular structure, motility and chemotaxis, genetic
manipulation, evolutionary genetics, ecology, tick interactions,
Lyme disease and relapsing fever pathogenesis, animal models, host
response, detection, and vaccines. The volume is essential for
anyone involved in Borrelia research and is strongly recommended
for microbiologists, immunologists, and physicians involved in
spirochete research, Lyme borreliosis, or relapsing fever. The book
is a recommended reference volume for all microbiology libraries.
In the past, Treponema research was severely handicapped because
the organisms were notoriously difficult to work with and were
unculturable in the laboratory. Powerful molecular and genetic
tools developed in recent years have been successfully used to
dramatically expand our understanding of treponemal diversity,
genomics, and cellular and molecular biology. Major breakthroughs
include sequencing of Treponema genomes and the development of
modern molecular methods. In recent years there has been an
explosion of new information that is summarized in the current
volume. Expert international authors critically review every aspect
of the molecular and cellular biology of these fascinating
organisms. The focus of this book is on recent advances and new
developments in Treponema research, in particular those resulting
from modern molecular and genetic methodologies. Topics covered
include the phylogenic diversity, comparative genomics, metabolism
and cultivation, motility, antigenic varia
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